4 Top Enzymes For Inflammation and Pain (Plus the #1 Mistake That Will Make Them Ineffective)

Herbs aren’t the only natural remedies that can curb inflammation. Proteolytic enzymes are super effective at blocking deadly chronic inflammation.

What’s Wrong With Inflammation?

So why is inflammation bad anyways? Well, it’s not always bad but when it becomes chronic, it is indeed bad.

When inflammation is doing what it’s supposed to, inflammation signals cause your immune cells to produce oxidative stress that is meant to kill pathogens like viruses or bacteria.


Inflammation also causes pain along with damage. So - yeah, it’s not good.

Now that you know why inflammation is bad, let’s look at the enzymes that inhibit it - and the pain that goes along with it.

Inflammation-Busting Enzymes

1. Serrapeptase (For Inflammation and Pain)

Serrapeptase has been shown in numerous human studies to fight inflammation and the effects of inflammatory disorders - acting “rapidly localized inflammation” and reducing swelling (a sign of inflammation) 1,2

Serrapeptase earns high praise from researchers, who say that the enzyme “possesses tremendous scope in combating inflammation” 3. A big reason why the enzyme is so successful at preventing inflammation is that it breaks down cyclooxygenase (COX) enzymes which are responsible for producing numerous inflammation-causing compounds 10†.

Serrapeptase also reduces pain-producing compounds called bradykinins 8. In one study examining the effect of serrapeptase on dental surgery patients, the enzyme caused a  “significant reduction” in “pain intensity” 9.

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2. Papain (For Inflammation)

Papain is an anti-inflammatory enzyme naturally found in papaya.

Papain (along with other enzymes) has been tested specifically against inflammation in those that experience chronic joint pain and the papain enzyme mixture “significantly reduced TGF-β1, a major inflammation signal in the body” .

3. Bromelain (For Pain)

This powerfully anti-inflammatory enzyme found in pineapple have been proven in clinical trials 5. Researchers even describe bromelain and a possible “alternative” to NSAID anti inflammatory drugs like Advil or aspirin 6.

Bromelain’s pain-killing properties “are thought to be the result” its ability to regulate the bradykinin pain-causing proteins 6

In one study, “bromelain administration resulted in significant decrease in pain and stiffness in patients with” knee cartilage damage 7.

4. Fungal Proteases

Proteolytic enzymes (like bromelain, papain, and serrapeptase mentioned above) are consistently anti-inflammatory. It may sound gross, but enzymes isolated from fungus have been shown in humans to reduce levels of the inflammatory marker C-reactive protein 11.

How To Take Enzymes

In order for these enzymes to be best absorbed, they need to pass through your stomach acid without getting degraded.

There are two things recommended in taking anti-inflammatory enzymes:

  • Take on an empty stomach (2 hours after a meal or at least 30 minutes before a meal)
  • Take a capsule that is especially coated to withstand stomach acid/li>

Enzymes are most effectively absorbed into your body if the make it past the stomach intact and are then absorbed into your bloodstream by route of your small intestine.

DRcaps® - The Right Way to Deliver Enzymes

Laboratory and animal tests have demonstrated the effectiveness of DRcaps® in delivering therapeutic ingredients past the stomach 13. Researchers describe this ability as “superior gastric-stability” 13.

DRcaps® provide a great way to deliver enzymes undamaged into your small intestine.

This is a special form of encapsulation help protect dietary supplement ingredients from stomach acid helping to ensure that the benefits of the product are not compromised.

DRcaps® are made from hypromellose, which is a sturdy polymer that protects the contents of the pill from acidic environments like the stomach.

Researchers also use DRcaps® in humans as a sure-fire way to deliver probiotics into the intestines of those with digestive disorders 14†.

So when buying anti-inflammatory enzymes, make sure they are coated with DRcaps®.

Having trouble getting around because of painful, swollen joints?

Inflammation could be to blame for your symptoms.  As we age, sometimes our immune systems go haywire and start attacking the harmless cartilage between our joints.

And while inflammation is normally necessary to help the immune system fight off invaders like viruses and bacteria -- it’s definitely NOT needed in places like your knees, shoulders, hands, wrists and back!


If occasional joint pain and stiffness is affecting your mobility at the worst possible times, and you’re looking for a natural way to help lessen the inflammation, give Nutracraft’s FlexiAid a try.

FlexiAid is formulated with all-natural ingredients that have been clinically shown to help reduce inflammation and ease pain, including serrapeptate, papain, bromelain, white willow bark, ginger root extract, fungal proteases and moreƗ all encapsulated inside DRCaps so it can be delivered undamaged where it is needed to work.

If you’re worried about dependence or addiction to prescription or over-the-counter pain relievers for joint pain, give FlexiAid a try.  Use it for 60 days risk-free. If for any reason you don’t enjoy greater freedom and mobility in your jointsƗ, with less painƗ, simply send us the empty bottle back for a refund of your purchase price

Click here to learn more about FlexiAid today.

Evan Burns

MSC in Nutrition

Evan Burns

MSC in Nutrition

Evan has years of experience researching and writing about the health effects of food and nutritional supplements.

He is especially passionate about nutritional pharmacology and the bioavailability, efficacy, and actions of supplements. He wants to spread knowledge about how effective diet and supplements can be at treating ailments and promoting well-being.

Although we often think of mobility issues as something that happens later on in life, the truth is that anyone at any age can be plagued by joint pain and stiffness.

Until now, the advice was pretty cut-and-dried: move more, take an anti-inflammatory, eat right… But while this is all good advice, it doesn’t get to the core problem that when it hurts to move, you don’t want to move!

Fortunately, a new method devised by scientists and researchers is helping to change how these aches and pains are treated. Dubbed the “RIP Method”, this pain-free strategy involves no surgery and no side effects -- and it’s something that anyone can benefit from right away.

Click here to find out why clinical researchers were surprised by how well these methods worked...